KLMED8004 Medisinsk statistikk Del I (Medical Statistics Part I).

KLH3004 Medisinsk statistikk (Medical statistics)

Autumn 2009

Eksamen 16 desember 2009 (norsk)

Exam 16 december 2009 (English)

Exam 16 December 2009 solutions

Re-scheduled exam (gjentatt eksamen): 10 June 2010.

KLMED8004 is aimed at PhD students within medicine and health sciences, master students, doctors, medical students, and other interested.

KLH3004 is the compulsory for ”MSc i Klinisk helsevitenskap” and “MSc in Excercise physiology and sport sciences”

Language

The lectures will be in Norwegian and English, se lecture plan below. The textbook and the exercises are in English. Compulsory group work with 3 compulsory exercises are a major part of the course. Some of these groups will use English.

The contents of KLH3004 and KLMED8004 are identical

KLMED8004 Part I (autumn) gives 7.5 credits (studiepoeng) and includes descriptive statistics, probability, and basic statistical analysis. KLMED8005 Part II (spring) gives 7.5 credits (studiepoeng) and includes mainly analysis of contingency tables, regression analyses (linear, logistic, and survival).

Prerequisites (Forkunnskaper)

Mathematics from ”videregående skole”: algebra, elementary functions, the exponential function and logarithms.

Course responsible

Professor Stian Lydersen, Unit for applied clinical research (AKF)

Telefon 72575428
e-post: stian.lydersen@ntnu.no

Enrolment (Påmelding)

Via StudentWeb. Do this before study start. Make sure you enrol for a group for the compulsory group work. This will be done at the first lecture.
For students not registrered at NTNU: (For studenter uten studierett ved NTNU, vennligst fyll ut oppmeldingsskjemaet som dere finner her under påmelding/eksamensmelding: http://www.ntnu.no/dmf/forskning/phd/emner)

Course secretary

Mariann Hansen
e-post: mariann.hansen@ntnu.no
Tlf. 73598660

Textbook

Bernhard Rosner (2006). Fundamentals of Biostatistics. 6th ed. ISBN:0-534-41820-1.

Supplementary literature with a less technical introduction to basic statistics:

In Norwegian: Odd Aalen m.fl.: Statistiske metoder i medisin og helsefag. Gyldendal 2006
Denne inneholder bl.a. en meget god innføring i sannsynlighetsregning.
In English: David Bowers: Medical statistics from scratch. 2nd edition. Wiley 2008.
A well written and easy to read introduction to data analysis.

Software

Some exercises require use of software. Some examples in the lectures will be shown using software. SPSS is the most used statistical software in medical research in Norway. Alternatives are Stata, MiniTab, or R. An introduction to Stata, SPSS and R will be given in the start of the course. It is sufficient to have basic knowledge of one of these softwares, for example SPSS.

Literature on software:

Stata: Rabe-Hesketh, S. and B. S. Everitt (2007). A Handbook of Statistical Analyses Using Stata. Chapman & Hall/CRC.

SPSS: Kinnear & Gray (2008). SPSS 15 Made Simple. Psychology Press.

SPSS Manuals: “SPSS Base User’s Guide” is a good introduction to SPSS available on NTNU, DMF: P:\programvare\SPSS16\Manualer

R: An Introduction to R (pdf, free) or Everitt, B. S. and T. Hothorn (2006). A Handbook of Statistical Analyses Using R. Boca Raton, Chapman & Hall/CRC.

Exercises

There are 3 compulsary exercises. Each exercise includes 8 parts. The group hands in its solution to the group teacher (gruppeveileder) shortly after the group teaching (veiledning)

Exercise 1

Exercise 2

Exercise 3

Lists of group participants are here

Time and place for group teaching is found here.

Group teaching (2 hours) is arranged prior to each handing in of exercises. The group shall have finished the exercise as much as possible before the group teaching. Attendance is compulsory, and attendance lists will be circulated. The group teacher corrects and approves the exercise for each group. Each participant must keep a file with paper copies of the approved exercises. The exercises and group teaching are the main part of the course evaluation.

Pensum [Curriculum]

Pensum er definert fra: [The curriculum refers to:]
Bernhard Rosner (2006).
Fundamentals of Biostatistics. 6th ed.
ISBN:0-534-41820-1.

1.
2: except 2.6, 2.7 and 2.11.
3: except 3.8.
4: except 4.10-4.13.
5: except 5.8.
6: except 6.3, 6.7, pages 207-209 (Interval estimation – Exact methods), 6.9, 6.10.
7: except 7.8, 7.9, 7.11.
8: except 8.6, 8.9, 8.11.
9.

Fundamentals of Biostatistics. 5th ed:

      * 1.

      * 2: except 2.6, and 2.7

      * 3.

      * 4: except 4.10-4.13.

      * 5: except 5.8.

      * 6: except 6.3, 6.7, pages 194-196 (Interval estimation – Exact methods), 6.9, 6.10.

      * 7: except 7.8, 7.10.

      * 8: except 8.6, 8.9, 8.11.

      * 9.

Course evaluation

To aid us in improving future courses, we ask all the course participants to fill inn a questionnaire at this web site: WebEvaluation

Final exam

There will be a final written exam with duration 4 hours on 16 December. The exam may be answered in English, Norwegian, Danish or Swedish. All printed and written aids, and calculator are allowed, according to “examination support code A”, see http://www.ntnu.no/studies/examinations/instructions (in Norwegian “Hjelpemiddelkode A” se http://www.ntnu.no/studier/eksamen/instruks).

Lecture plan

In addition, time plan for group teaching (øvingsveiledning) is here

Some lectuers are taught two times. For example, “Probability” (Sannsynlighet”), Chaper 3 in the textbook, is taught 26/8 at 1415-1600 (in a Block Week for Master i Klinisk helsevitenskap) and 2 september (primarily aimed at KLMED8004). The contents of the two lectures are identical, but we aim at teaching in English those at 1215-1400 (for KLMED8004).

Week	Date	Time	Place	Teacher	Subject	Planned language	Rosner chapter	Primarily for	Lecture notes
34	19.8	1230-1515	02S21	PR	Innføring i Stata (Introduction to Stata)	N		Interesserte	Slides
34	24.8	1300-1600	MTA	ES	Innføring i statistikkprogrammet R (Introduction to R) *)	N		Interesserte	Nærmere info
35 BU	25.8	0815-1600	Datasal 3 etg Nevro	JHB	Innføring i SPSS m / øvinger	N		Master i klinisk helsevitenskap	Slides
35 BU	26.8	1215-1400	LA21	ES	First ordinary lecture. Introduction. Descriptivbe statistics. (Første ordinære forelesning: Introduksjon. Deskriptiv statistikk)	E/N	1,2	KLMED8004 KLH3004	Slides Nor Slides Eng
35 BU	26.8	1415-1600	LA21	ØS	Probability (Sannsynlighet)	N	3	KLH3004	Slides Nor Slides Eng
35 BU	27.8	0815-1000	LS21	HJ	Random variable. Discrete probability distribution. (Tilfeldig variabel. Diskret sannsynlighetsfordeling)	N	4,5	KLH3004	Slides Nor Slides Eng
36	31.8	0830-1200	ØHA11	SL	Innføring i SPSS, for interesserte (Introduction to SPSS for those interested)	N		Interesserte	Slides
36	2.9	1215-1400	02S21	SL	Probability (Sannsynlighet)	E	3	KLMED8004	Slides Nor Slides Eng
37	9.9	1215-1400	MTA	HJ	Random variable. Discrete probability distribution. (Tilfeldig variabel. Diskret sannsynlighetsfordeling)	E	4, 5	KLMED8004	SlidesNor Slides Eng
38 BU	16.9	1215-1400	MTA	PR	Continuous probability distribution (Kontinuerlig sannsynlighetsfordeling)	E	5	KLMED8004 KLH3004	Slides nor Slides Eng
38 BU	16.9	1415-1600	MTA	ML	Estimation and properties of the mean. The central limit theorem. (Estimering og egenskaper til gjennomsnitt. Sentralgrenseteoremet)	N	6	KLH3004	slides Notat HR Nor
39					Guidance and hand for Exercise I (Veiledning og innlevering Øving I)
40	30.9	1215-1400	LA21	ML	Estimation and properties of the mean. The central limit theorem. (Estimering og egenskaper til gjennomsnitt. Sentralgrenseteoremet)	E	6	KLMED8004	slides Notat HR Nor
41 BU	7.10	1215-1400	ØHA11	ML	One sample test of hypothesis (Hypotesetest, ett utvalg)	E/N	7	KLMED8004 KLH3004	slides
41 BU	7.10	1415-1600	ØHA11	SL	Two sample test of hypothesis (Hypotesetest, to utvalg)	N	8	KLH3004	Slides English Slides norsk
42					The course week at DMF No ordinary lectures. (Kursuka ved DMF. Ingen ordinære forelesninger).
43	21.10	1215-1400	02S21	SL	Two sample test of hypothesis (Hypotesetest, to utvalg)	E	8	KLMED8004	Slides English Slides norsk
44					Guidance and hand for Exercise II (Veiledning og innlevering Øving II)
45	4.11	1215-1400	ØHA11	GJ	Power and sample size (Teststyrke, utvalgsstørrelse)	E	7,8	KLMED8004	Slides eng Slides norsk
46 BU	11.11	1215-1400	KBA	ES	Non-parametric methods (Ikke-parametriske metoder)	E/N	9	KLMED8004 KLH3004	Slides Notat norsk Note Eng.pdf
46 BU	11.11	1415-1600	KBA	GJ	Power and sample size (Teststyrke, utvalgsstørrelse)	N	7,8	KLH3004	Slides eng Slides norsk
47					Guidance and hand for Exercise II (Veiledning og innlevering Øving II)
48
49
50	11.12	1000-1500	LS21	SL, ML, ØS	Lecturers are available to answer questions
51	14.12	1000-1200	LS41	SL, ML, ØS	Lecturers are available to answer questions
51	16.12		Place		Written Exam

BU means Block Week for Master i klinisk helsevitenskap

*) You must bring your laptop with R installed., freely available from www.r-project.org
R is also available from ”programvarebiblioteket på Nytt sykehus”.
We will follow Owen: The R Guide

Rooms:

O2S21: 1st floor, west, 1902-building

MTA: ground floor, MTFS

LA21: 1st floor, middle/north, Laboratory centre

LS21: 1st floor, east, Laboratory centre

ØHA11: ground floor, Øya Helsehus

KBA: ground floor, north, Women Children centre

Teachers

Stian Lydersen (SL)
Johan Håkon Bjørngård (HJB)

Geir Jacobsen (GJ)
Harald Johnsen (HJ)
Mette Langaas (ML)

Pål Romundstad (PR)
Eirik Skogvoll (ES)

Øyvind Salvesen (ØS)

Redaktør: stian.lydersen@ntnu.no